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Comparative Study of Hypofractionated Palliative Radiotherapy 17 Gy in 2 Fractions vs. 30 Gy in 10 Fractions in Lethal Locally Advanced Non-small Cell Lung Cancer
Kamrun Nahar Tania,
Jannatun Nisa,
Moarraf Hossen,
Muhammad Masudul Hassan Arup,
Muhammad Abdullah-Al-Noman,
Mohammad Shaiful Hassan Shameem,
Sonya Begum,
Mohammad Arifur Rahman
Issue:
Volume 8, Issue 2, June 2023
Pages:
20-26
Received:
21 February 2023
Accepted:
13 March 2023
Published:
10 May 2023
Abstract: Background: Lung cancer kills the most people worldwide. Most Bangladeshi patients had regionally advanced surgically inoperable Non-Small Cell Lung Cancer (NSCLC), a deadly disease. Radiotherapy to main tumor and regional lymphatics with chemotherapy is conventional treatment. Objective: This study was done to investigate the symptoms relief and treatment related toxicities in hypo fractionated 17 Gy in 2 fractions which is effectively comparable to 30 Gy in 10 fractions. Methods: A total 60 patients were divided equally into Arm A and Arm B with locally advanced stage IIIA, and stage IIIB NSCLC patients with the objective to compare palliation of symptoms and to assess the toxicity profile. This Quasi Experimental study was carried out from January 2018 to December 2018 in the department of Radiation oncology, National Institute of Cancer Research and Hospital. Cases of Arm A were treated with 17 Gy radiotherapy in 2 fractions and those of Arm B were treated with 30 Gy radiotherapy in 10 fractions. Results: The mean age was 49.3±8.8 and 52.2±8.1 years for the Arm- A and the Arm-B respectively. Most patients in both groups were males, 80% in group A and 90% in group B. Adenocarcinoma (Arm A-70%, Arm B- 66.7%) was the most common pathological subtype in both groups, followed by Squamous cell carcinoma (30%, 33.3% respectively). This study showed that there was a significant palliation of these symptoms following radiotherapy as reported by patients and as assessed clinically with no statistically significant difference between two Arms. Hemoptysis had the highest rate of improvement, 100% in both arms and improvement in chest pain by 83.3% in arm A and 70% in Arm B. Cough was improved in 83.3% and 67.7% and dyspnea was palliated in 80.0% and 70.0% of patients in Arm A and Arm B, respectively as per clinical assessment of the patients. The early toxicities in both arms had no significant difference. Patients with locally advanced inoperable NSCLC have poor prognosis and less survival. The first goal was acceptable symptoms control as cough, dyspnoea, haemoptysis and chest pain. Conclusion: The result of this study showed that a significant palliation of symptoms with minimum toxicities improving quality of life following radiotherapy as reported by patients also assessed clinically and radiographically with no statistically significant difference among both arms.
Abstract: Background: Lung cancer kills the most people worldwide. Most Bangladeshi patients had regionally advanced surgically inoperable Non-Small Cell Lung Cancer (NSCLC), a deadly disease. Radiotherapy to main tumor and regional lymphatics with chemotherapy is conventional treatment. Objective: This study was done to investigate the symptoms relief and t...
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Epidemiological and Therapeutic Aspects of the Single Visit Approach in the Management of Precancerous Lesions of the Cervix in Guinea Conakry in 2022
Soumah Aboubacar Fode Momo,
Conte Ibrahima,
Leno Daniel Williams Atanasse,
Sylla Ibrahima
Issue:
Volume 8, Issue 2, June 2023
Pages:
27-31
Received:
27 April 2023
Accepted:
12 May 2023
Published:
22 May 2023
Abstract: Objective: to evaluate the epidemiological and therapeutic aspects of the single visit approach in the management of precancerous lesions of the cervix in the CECAP sites of Conakry in 2022. Methodology: This was a multicenter cross-sectional descriptive study, using retrospective data at the six CECAP sites from July 1 to Conakry. Three data collection tools: the individual form, a screening register, and a monthly summary sheet or reporting template, were used to track key single-visit service variables: the number of women screened using VIA, proportion of women screened positive for VIA and proportion of women screened VIA positive who received cryotherapy on the same day, KoBo Collect served the collections and the analysis was carried out by the software EPI info version 7.2 6. Results: during our three-month study, in the six pilot sites of Conakry, 786 women were screened, of whom 3.18% (25/786), had IVA+, 62.5% benefited from cryotherapy the same day, it was postponed in 37.5% of cases, the program did not train providers in the management of large lesions, which is one of the limitations of our study. Conclusion: Visual inspection with acetic acid is a simple test, requiring minimal infrastructure and expense, little provider training. The integration of VIA with cryotherapy at the primary care level in the communal medical centers of the city of Conakry, could constitute a feasible program for the prevention of cervical cancer in Guinea.
Abstract: Objective: to evaluate the epidemiological and therapeutic aspects of the single visit approach in the management of precancerous lesions of the cervix in the CECAP sites of Conakry in 2022. Methodology: This was a multicenter cross-sectional descriptive study, using retrospective data at the six CECAP sites from July 1 to Conakry. Three data colle...
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The Role of Peptide Immunotherapy in the Treatment of Cervical Dysplasia: Clinical Cases
Оlga Bulavenko,
Тetiana Lunko,
Оleksii Таtskyy,
Тetiana Fomina,
Мaria Pikul,
Оleksandr Zdanevych,
Mykhailo Каzarnovskyy,
Victor Zadorozhnyy,
Svitlana Тurbanist,
Svitlana Pysmenna,
Olena Yamkova-Bodnaruk,
Liudmyla Lytvynchuk
Issue:
Volume 8, Issue 2, June 2023
Pages:
32-38
Received:
12 April 2023
Accepted:
15 May 2023
Published:
25 May 2023
Abstract: Introduction. Since one of the main factors determining the pathogenic effect of HPV infection is local immunodeficiency, a number of authors suggest using various cytokines and immunomodulators. Recently, peptide-based agents have been increasingly used in routine clinical practice. Objective. To study the effect of peptide immunocorrection on molecular and cellular factors affecting the course of grade II cervical dysplasia (CIN2) as a precancerous process and to evaluate the effectiveness of the proposed regimen. Materials and methods. The study included 2 groups of patients aged 28 to 44 years who were colposcopically and cytologically diagnosed with grade 2 cervical dysplasia. Clinical monitoring, determination of HPV by PCR, immunohistochemical studies of biomarkers of inflammation and proliferation, as well as counting of T-lymphocytes in cervical mucus preparations were performed before treatment, after treatment, after 6 weeks and after 3 months. Results. During the study of the expression level of pro-oncogenic interleukin IL-8 and anti-oncogenic IL-12, it was established that in both observation groups after the immunotherapy, a tendency to decrease the pro-oncogenic potential of cervical mucus was noted. Analysis of the level of expression of the cell proliferation marker Ki-67 in the clinical monitoring groups showed that the proposed therapy schemes reduced the proliferative potential of the cervical epithelium. The number of active cytotoxic lymphocytes in the cervical mucus in both observation groups predictably increased after the use of local immunotherapy. The study showed that immunotherapy of cervical dysplasia with the use of peptides demonstrated significantly better clinical results compared to the reference group. Conclusion. Taking into account the obtained research results and the given clinical cases, peptide immunocorrection can be reasonably recommended as an immunological component in the treatment of cervical dysplasia (ASCUS and LSIL).
Abstract: Introduction. Since one of the main factors determining the pathogenic effect of HPV infection is local immunodeficiency, a number of authors suggest using various cytokines and immunomodulators. Recently, peptide-based agents have been increasingly used in routine clinical practice. Objective. To study the effect of peptide immunocorrection on mol...
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