Reconstructive Angioplasty During Secondary Cytoreductive Surgery Performed in Patients with Recurrent Ovarian Cancer
Boyko Valeriy,
Kharchenko Kateryna,
Prasol Vitaliy,
Uderbayeva Gukmira
Issue:
Volume 2, Issue 3, June 2017
Pages:
51-56
Received:
27 January 2017
Accepted:
11 April 2017
Published:
18 May 2017
DOI:
10.11648/j.ijcocr.20170203.11
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Abstract: Background: Tumor involvement of major vessels, especially the iliac arteries, is used to be the significant limitation for secondary cytoreductive surgery (SCRS) of recurrent ovarian cancer (ROC). Materials and Methods: Patients with ROC (n=46) who were treated in the State Establishment «Zaitsev V. T. Institute of General and Emergent Surgery of the Academy of Medical Sciences of Ukraine» during January 2009 – September 2015. All patients received SCRS with restoration and reconstructive angioplasty of the external iliac artery: I group (n=24) – alloprosthesis; II group (n=22) – autoartery angioplasty. Results: Duration of surgery was in Group I and Group II 466.3±11.2 min vs 454.8±10.3 min respectively, р>0.05. Postoperative complications occurred in 10 (21.7%) patients (25% in Group I; 18.2% in Group II). The incidence of nonspecific early postoperative complications was 25% in Group I and 19.1% in Group II; p=0.3. The incidence of specific complications was higher in allograft group (12.3% vs 4.5%; р=0.036). There was statistically significant difference between the groups in stage distribution of postoperative complications (р=0.03). There were no cases of late specific and non-specific complications. Postoperative mortality was 0%. Duration of hospital stay in Group I was 21.5±2.3 days vs 12.1±1.7 days; in Group II, p=0.02. SCRS was optimal in all cases. Median follow-up was 42.5 months (range 7-64 months). There was no significant difference among groups in the recurrence rate, medians disease-free and overall survival. Conclusion: Usage of the internal iliac artery as autograft during SCRS with restoration and reconstruction angioplasty of external iliac artery leads to reducing risk of specific complications (infection, rejection) and prevents development of destructive processes in the graft wall. There is no negative impact of such surgical approach on the rates of recurrence and overall survival of ROC patients.
Abstract: Background: Tumor involvement of major vessels, especially the iliac arteries, is used to be the significant limitation for secondary cytoreductive surgery (SCRS) of recurrent ovarian cancer (ROC). Materials and Methods: Patients with ROC (n=46) who were treated in the State Establishment «Zaitsev V. T. Institute of General and Emergent Surgery of ...
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Knowledge and Practice of Breast Self-Examination Among Female Nursing Students in University of Maiduguri, Borno State, Nigeria
Habu Haruna,
Emmanuel Okechukwu Chukwu,
Inuwa Ahmadu,
Kever Robert Teryila,
Maigari Babaji,
Lola Nelson,
Dathini Hamina
Issue:
Volume 2, Issue 3, June 2017
Pages:
57-64
Received:
30 March 2017
Accepted:
25 April 2017
Published:
20 June 2017
DOI:
10.11648/j.ijcocr.20170203.12
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Abstract: Breast cancer appears to be a disease of both developing and developed nations; it is the leading cause of death universally and responsible for about 12% of death throughout the world. The risk of breast cancer increases with age. The primary factor that increases breast cancer in women includes certain genetic mutations, personal family history of breast cancer and biopsy confirming hyperplasia. The purpose of breast self-examination is to learn the topography of the breast which will allow one to notice changes in the breast such as breast lumps or masses. Breast self-examination is done monthly between the 7th and 10th day of menstrual cycle which is early identification of abnormality and is also a low risk procedure that do not cause pain or discomfort. The aim of the study is to evaluate the knowledge and practice of female students in relation to breast self-examination. A non-experimental descriptive study was used to examined the knowledge and practice of breast self-examination among female nursing students of the department of nursing science, university of Maiduguri. A self-structured questionnaire with a content validity and reliability of 0.82 and 0.78 respectively. Using Yemen’s formula, sample size of one hundred and nine (109) respondents were selected from 100 level to 500 level nursing students using simple random sampling technique after the use of stratified random sampling which ensured that each strata (class level) was represented in the study. All data were analyzed using frequency and percentages and presented in tables. Chi-square statistic with 0.05 level of significant was used in testing the developed hypothesis. The findings shows that the majority of the students have knowledge on breast self-examination and they also practice breast self-examination. All hypotheses tested showed that there is significant relationship between knowledge, source of information, age and practice of breast self-examination as all the calculated values were greater than the critical value (table value). The researchers recommend that effort should be sustained in ensuring nursing students continue to update their knowledge and skills of breast self-examination and also educate their colleagues who have poor knowledge of BSE with the view to improving their practice.
Abstract: Breast cancer appears to be a disease of both developing and developed nations; it is the leading cause of death universally and responsible for about 12% of death throughout the world. The risk of breast cancer increases with age. The primary factor that increases breast cancer in women includes certain genetic mutations, personal family history o...
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Discovery, Chemistry, Anticancer Action and Targeting of Cisplatin
Rajapakse Mudiyanselage Gamini Rajapakse,
Shashiprabha Punyakantha Dunuweera
Issue:
Volume 2, Issue 3, June 2017
Pages:
65-74
Received:
8 April 2017
Accepted:
24 April 2017
Published:
22 June 2017
DOI:
10.11648/j.ijcocr.20170203.13
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Abstract: Cisplatin is the first anticancer drug based on inorganic complexes which was discovered accidentally by Rosenberg in 1965. Cisplatin is now used to treat a wide range of cancers such as head and neck testicular, small-cell lung and non-small-cell lung, bladder, cervical and ovarian cancers. Cisplatin has become the premier in combination therapy for solid tumours such as gastric, bladder, cervical, ovarian, lung, breast, head and neck cancers and some malignant mesothelioma and some less common cancers. This review begins with an introduction to the accidental discovery of cisplatin highlighting the amazing fact of serendipity involved in drug discovery. This will follow a reviewing of chemistry of cisplatin, identification of cis and trans isomers of diamminedicholoroplatinum(II). As for the most relevance to Pharmacy the action of cisplatin is reviewed next. Highlighted there are the reasons for cisplatin toxicity and hence ways and means of reducing cytotoxicity of cisplatin to healthy cells. Finally, the work on encapsulation of cisplatin in porous calcium carbonate nanoparticles for safe and targeted delivery to cancerous cells for more effective and selective action on cancer cells will be discussed.
Abstract: Cisplatin is the first anticancer drug based on inorganic complexes which was discovered accidentally by Rosenberg in 1965. Cisplatin is now used to treat a wide range of cancers such as head and neck testicular, small-cell lung and non-small-cell lung, bladder, cervical and ovarian cancers. Cisplatin has become the premier in combination therapy f...
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