Doxorubicin-Induced Cardiotoxicity: Molecular Mechanism and Protection by Conventional Drugs and Natural Products
Hayder M. Alkuraishy,
Ali I. Al-Gareeb,
Hany Akeel Al-hussaniy
Issue:
Volume 2, Issue 2, April 2017
Pages:
31-44
Received:
9 February 2017
Accepted:
1 March 2017
Published:
20 March 2017
DOI:
10.11648/j.ijcocr.20170202.12
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Abstract: Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-induced cardiotoxicity. Doxorubicin therapy augments oxidative stress and disturbs cytosolic calcium homeostasis, increases intracellular calcium levels from the sarcoplasmic reticulum through activation of the ryanodine receptor and by blighting calcium clearance systems in cardiomyocytes. In this condition the researchers trying to develop cardio-protective strategy to decrease this cardio-toxic effect without decreasing its anticancer effect. Now day's oncologists and pharmacologist work to find out how to decrease the cardiovascular risk and prevent doxorubicin adverse cardiovascular effect. Therefore, the aim of this study was to illustrate the molecular mechanism and possible amelioration of doxorubicin induced-cardiotoxicity via conventional drugs and natural products.
Abstract: Doxorubicin is useful anticancer drug because it's used in treatment of acute leukemia, Hodgkin's and non-Hodgkin's lymphomas, and many other malignant neoplasm. The mechanism of doxorubicin induce cardiotoxicity is multifactorial includes free radical stress, mitochondrial dysfunction and calcium overload these are the main causes of doxorubicin-i...
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The Influence of Serum Vitamin A on Lung Cancer Risk
Issue:
Volume 2, Issue 2, April 2017
Pages:
45-50
Received:
28 February 2017
Accepted:
11 March 2017
Published:
27 March 2017
DOI:
10.11648/j.ijcocr.20170202.13
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Abstract: The objective of this study was to evaluate the association of serum level vitamin A with the incidence of lung cancer (LCa). An analysis, using a prospective study design, was conducted among a cohort of 3,086 men and women, ages 25 to 74 years, from the First National Health and Nutrition Examination Survey-Epidemiologic Follow-up Study. Using Cox proportional hazards regression analysis, inverse associations between serum vitamin A and LCa risk were observed in all models. These findings suggest that increased serum vitamin A may protect against LCa. Additional studies, addressing the limitations encountered in this analysis, are needed to validate the protective role vitamin A may play against LCa risk.
Abstract: The objective of this study was to evaluate the association of serum level vitamin A with the incidence of lung cancer (LCa). An analysis, using a prospective study design, was conducted among a cohort of 3,086 men and women, ages 25 to 74 years, from the First National Health and Nutrition Examination Survey-Epidemiologic Follow-up Study. Using Co...
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