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Peritoneal Cancer Indexes in Ovarian Carcinomatosis: Correlation Between CT and Intraoperative Results and Survival
Lombardo Galera Sagrario,
Espejo Herrera Juan Jose,
López Redondo Celia,
Pérez Montilla Maria Eugenia,
Muñoz Casares Francisco Cristobal,
Zurera Tendero Luis Jesus
Issue:
Volume 2, Issue 4, August 2017
Pages:
75-81
Received:
26 January 2017
Accepted:
27 May 2017
Published:
1 August 2017
DOI:
10.11648/j.ijcocr.20170204.11
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Abstract: The aim of this study is to value the performance of computed tomography (CT) for the detection of ovarian peritoneal carcinomatosis (PC). We review retrospectively abdominopelvic CT and compare them with surgical reports to value the correlation between surgical and radiological PC indexes and survey. We compare the peritoneal tumor implants detected on CT performed before surgery with pathology results obtained after surgery. 47 patients with an average age of 58 years are investigated. Tumor localization and size are documented applying Sugarbaker´s Peritoneal Carcinomatosis Index (PCI) in both, radiological and surgical investigations, which divide the entire abdominal and intestinal regions into 13 spaces. In each one, the bigger visible lesion is measured and scored between 0 and 3. In our study, the correlation of Pearson shows there is a moderate correlation between the findings of the PCI obtained in the TC and surgical findings, appreciating a general low correlation in all regions, although the better results belong to regions 1, 2, 0 and 10. Also we observed a lower survival to greater PCI regarding carcinomatosis index in both TC and surgery. All patients received systemic chemotherapy before surgery, so its effect on the size of the peritoneal implants could explain the low correlation. In conclusion, we can consider that TC is a useful tool for the planning of the surgery and the preoperative treatments. The peritoneal cancer index is a significant index of survival in ovarian cancer patients and by using PCI a detailed evaluation of the peritoneal spread is possible being useful as a prognostic factor.
Abstract: The aim of this study is to value the performance of computed tomography (CT) for the detection of ovarian peritoneal carcinomatosis (PC). We review retrospectively abdominopelvic CT and compare them with surgical reports to value the correlation between surgical and radiological PC indexes and survey. We compare the peritoneal tumor implants detec...
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Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients
Tehseen Hassan,
Wasim Qureshi,
Showkat Ahmad Bhat,
Sabhiya Majid,
Manzoor R. Mir,
Purnima Shrivastava
Issue:
Volume 2, Issue 4, August 2017
Pages:
82-85
Received:
2 July 2017
Accepted:
13 July 2017
Published:
15 August 2017
DOI:
10.11648/j.ijcocr.20170204.12
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Abstract: Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentration of Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) in breast cancer (BC) patients and healthy individuals by using atomic absorption spectrophotometer. Results: There was a significant (p<0.05) decline in the concentration of Se in serum samples of BC patients as on comparison with the healthy individuals. Concentration of Cu of BC patients was increased significantly (p<0.05) on comparison with the healthy individuals. There was a significant (p<0.05) decline in the concentration of Zn in BC patients on comparison with the healthy individuals. Level of difference of Fe remain insignificant (p>0.05) in serum of BC patients. There was a significant decline in the concentration of Se and Zn while high level of serum copper in breast cancer patients, as compared with normal healthy controls. Conclusion: We found a significant association between trace elements (serum selenium, zinc and copper) with breast cancer.
Abstract: Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentra...
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The Association of Toxoplasma gondii Infection in Breast and Colorectal Cancer Patients
Dalya Falih Ahmed,
Entsar Jabbar Saheb
Issue:
Volume 2, Issue 4, August 2017
Pages:
86-92
Received:
14 July 2017
Accepted:
25 July 2017
Published:
18 August 2017
DOI:
10.11648/j.ijcocr.20170204.13
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Abstract: Toxoplasma gondii is an obligatory intracellular protozoan parasite which is a major opportunistic pathogen in patients who are immunocompromised that having cancer disease. Little is known about the epidemiology of T. gondii infection in patients who are immunocompromised. This study investigate the possible association of T. gondii infection with cancer disease via determining the seropositivity rate of anti T. gondii antibodies (IgG and IgM) in Iraqi patients infected with breast and colorectal cancer and investigate the level of IL-6 in the studying groups. Overall 223 women serum samples that included 112 healthy controls samples and 111 samples with breast cancer (CA. Breast) and colorectal cancer (CA. CRC) enrolled in this study. The participants were tested for T. gondii immunoglobulins (IgG and IgM) antibodies and (IL-6) levels. The results showed that 86 (77.46%) cancer sample out of 111 samples and 23 (20.54%) out of 112 control samples were positive to anti T. gondii IgG. The seropositive rate of anti T. gondii IgG in CA. Breast and CA. CRC patients (77.50%, 77.42%) respectively compared with control group (20.54%). The present results revealed that the higher percentages for anti-T. gondii IgG and IL-6 titer was among patients with CA. Breast and CA. CRC whose are seropositive to anti T. gondii IgG. In regard to the tumor size, higher mean levels of IgG and IL-6 was shown in the tumor size (> 5 cm). Concerning to the tumor stages, the highest mean titer of IgG and IL-6 in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in stage (IIIC). According to the grade status, the highest mean titer of IgG Abs and IL-6 was in patients with CA. Breast and CA.CRC whose are seropositive to anti-T. gondii IgG was in grade (G3). The increased levels of anti-T. gondii IgG and IL-6 was significantly higher in CA. Breast and CA. CRC patients that infected with T. gondii compare with healthy control. Thus, anti-T. gondii IgG test and circulating levels of inflammatory cytokines has to be taken into consideration as markers for staging of the cancers.
Abstract: Toxoplasma gondii is an obligatory intracellular protozoan parasite which is a major opportunistic pathogen in patients who are immunocompromised that having cancer disease. Little is known about the epidemiology of T. gondii infection in patients who are immunocompromised. This study investigate the possible association of T. gondii infection with...
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The Role of Ageing, Inflammation and Maspin in the Early Stages of Prostatic Malignant Transformation
Kalin Petrov Kalchev,
Alexander Ivanov Hinev,
Alkwin Wanders,
Alexander Georgiev Otsetov
Issue:
Volume 2, Issue 4, August 2017
Pages:
93-98
Received:
29 June 2017
Accepted:
26 July 2017
Published:
25 August 2017
DOI:
10.11648/j.ijcocr.20170204.14
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Abstract: Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race and genetics, which are well-recognized risk factors for prostatic carcinoma, epigenetics play also a significant role in the initiation and progression of prostatic carcinoma. DNA methylation in the CpG gene islands is a key player in the regulation of gene expression and silencing, and significantly contributes to the disease development. Progression of cancer is associated with the loss of several tumor suppressor genes such as Maspin through mutations or epigenetic silencing. Epigenetic silencing of Maspin seems to be one of the earliest somatic change, contributing to the development of prostatic carcinoma in the human prostate.
Abstract: Prostate cancer (PCa) progression is an intricate step-wise process, starting from malignant transformations in the benign prostatic epithelium. The hallmark of PCa is the long period of its development from premalignant transformations in the benign prostatic epithelium towards clinically active carcinoma. Along with the age, inflammation, race an...
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