Volume 4, Issue 2, April 2019, Page: 10-24
Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature
Azka Ali, Department of Internal Medicine, University of Florida, Gainesville, USA
Raphael Charles Bosse, Department of Internal Medicine, University of Florida, Gainesville, USA
Bently Patrick Doonan, Department of Internal Medicine, University of Florida, Gainesville, USA
Preeti Narayan, Division of Hematology and Oncology, University of Florida, Gainesville, USA
Grant Alan Jester, Department of Internal Medicine, University of Florida, Gainesville, USA
Jess David Delaune, Department of Internal Medicine, University of Florida, Gainesville, USA
Jacob Leo Barish, Department of Internal Medicine, University of Florida, Gainesville, USA
Samantha Leigh Welniak, Department of Internal Medicine, University of Florida, Gainesville, USA
Hannah Friggle Norton, Health Science Center Libraries, University of Florida, Gainesville, USA
Coy Don Heldermon, Division of Hematology and Oncology, University of Florida, Gainesville, USA
Received: Feb. 21, 2019;       Accepted: Apr. 8, 2019;       Published: Jun. 11, 2019
DOI: 10.11648/j.ijcocr.20190402.12      View  52      Downloads  12
Abstract
First introduced in 1963, ommaya reservoirs (OmRs) are indwelling intraventricular catheters used for decompression of hydrocephalus, antibiotics, and chemotherapy delivery. They are important alternatives when lumbar punctures are not practical or when long-term administration of medications is needed. Despite being used for over 50 years, placement of these devices can still contribute to significant morbidity and mortality. We performed a single-center retrospective review at the University of Florida Cancer Center evaluating OmR related complications in patients in whom OmR was placed for chemotherapy. We also conducted a systematic review of OmR related and LP complications in setting of chemotherapy delivery. 13 patients met criteria for inclusion in this retrospective study. Time points evaluated for complications were: placement, up to 6 months, 6-12 months, > 12 months, removal and post-discharge. Our institutional data showed a complicated rate of <7% at each time point. For systematic review, 38 studies were reviewed for OmR data, and 8 studies were reviewed for LP data. Infectious complications were more prevalent in OmR studies with statistical significance (p=0.0017), whereas noninfectious complications were more prevalent in LP studies with statistical significance (p=0.0004). This study compared complication rates from infectious and non-infectious sources between patients receiving intrathecal chemotherapy through Ommaya reservoirs versus lumbar puncture. OmR can be very useful in long-term administration of medication, and the relatively high complication rate (especially infectious) can be deemed an acceptable risk for patient population with high morbidity.
Keywords
Ommaya Reservoir, Lumbar Puncture, Chemotherapy
To cite this article
Azka Ali, Raphael Charles Bosse, Bently Patrick Doonan, Preeti Narayan, Grant Alan Jester, Jess David Delaune, Jacob Leo Barish, Samantha Leigh Welniak, Hannah Friggle Norton, Coy Don Heldermon, Ommaya Reservoir Related Complications: A Single Center Experience and Review of Current Literature, International Journal of Clinical Oncology and Cancer Research. Vol. 4, No. 2, 2019, pp. 10-24. doi: 10.11648/j.ijcocr.20190402.12
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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