Volume 3, Issue 6, December 2018, Page: 72-77
Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case
Emily Bryer DO, Department of Internal Medicine, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
David Henry MD, Department of Hematology and Oncology, Pennsylvania Hospital, Philadelphia, Pennsylvania, USA
Received: Mar. 22, 2019;       Accepted: Apr. 28, 2019;       Published: May 27, 2019
DOI: 10.11648/j.ijcocr.20180306.11      View  28      Downloads  10
Abstract
Gestational trophoblastic tumors are a heterogeneous and aggressive group of neoplasms. Choriocarcinoma, an extremely rare subset of gestational trophoblastic tumor, is often metastatic at diagnosis and typically follows a pregnancy that is either ectopic or molar. We present a critical review of choriocarcinomas with an emphasis on choriocarcinomas of ovarian origin which are even more uncommon with an incidence estimated at 1 per 369 million. This manuscript also includes a case of a woman with polycystic ovarian syndrome who required assisted conception to conceive her daughter and then developed a rare extrauterine gestational ovarian choriocarcinoma eighteen months following her antecedent healthy pregnancy with uncomplicated delivery. Many aspects of this presentation are unique, even for such an extraordinary tumor; some of these include the absence of vaginal bleeding, the presence of unilateral pulmonary metastases, and an overwhelmingly positive serum β-hCG with a negative urine β-hCG. While such a discrepancy in urine and serum β-hCG has been reported in gestational trophoblastic disease following molar pregnancies, to our knowledge it has not yet been reported in choriocarcinomas following a normal pregnancy.
Keywords
Gestational Trophoblastic Disease, Ovarian Choriocarcinoma, Beta-Human Chorionic Gonadotropin, Pulmonary Metastases
To cite this article
Emily Bryer DO, David Henry MD, Gestational Ovarian Choriocarcinoma: A Review of the Literature and Presentation of a Perplexing Case, International Journal of Clinical Oncology and Cancer Research. Vol. 3, No. 6, 2018, pp. 72-77. doi: 10.11648/j.ijcocr.20180306.11
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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