Volume 2, Issue 3, June 2017, Page: 65-74
Discovery, Chemistry, Anticancer Action and Targeting of Cisplatin
Rajapakse Mudiyanselage Gamini Rajapakse, Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka
Shashiprabha Punyakantha Dunuweera, Department of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka
Received: Apr. 8, 2017;       Accepted: Apr. 24, 2017;       Published: Jun. 22, 2017
DOI: 10.11648/j.ijcocr.20170203.13      View  1932      Downloads  100
Abstract
Cisplatin is the first anticancer drug based on inorganic complexes which was discovered accidentally by Rosenberg in 1965. Cisplatin is now used to treat a wide range of cancers such as head and neck testicular, small-cell lung and non-small-cell lung, bladder, cervical and ovarian cancers. Cisplatin has become the premier in combination therapy for solid tumours such as gastric, bladder, cervical, ovarian, lung, breast, head and neck cancers and some malignant mesothelioma and some less common cancers. This review begins with an introduction to the accidental discovery of cisplatin highlighting the amazing fact of serendipity involved in drug discovery. This will follow a reviewing of chemistry of cisplatin, identification of cis and trans isomers of diamminedicholoroplatinum(II). As for the most relevance to Pharmacy the action of cisplatin is reviewed next. Highlighted there are the reasons for cisplatin toxicity and hence ways and means of reducing cytotoxicity of cisplatin to healthy cells. Finally, the work on encapsulation of cisplatin in porous calcium carbonate nanoparticles for safe and targeted delivery to cancerous cells for more effective and selective action on cancer cells will be discussed.
Keywords
Anticancer Drug, Discovery of Cisplatin, Chemistry of Cisplatin, Action of Cisplatin, Ways of Reducing Cytotoxicity, Encapsulation, Targeted-Delivery, Slow-Release
To cite this article
Rajapakse Mudiyanselage Gamini Rajapakse, Shashiprabha Punyakantha Dunuweera, Discovery, Chemistry, Anticancer Action and Targeting of Cisplatin, International Journal of Clinical Oncology and Cancer Research. Vol. 2, No. 3, 2017, pp. 65-74. doi: 10.11648/j.ijcocr.20170203.13
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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